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1

Advances with using CRISPR/Cas-mediated gene editing to treat infections with hepatitis B virus and hepatitis C virus

Moyo, Buhle, Bloom, Kristie, Scott, Tristan, Ely, Abdullah, Arbuthnot, Patrick

Journal:

Year:

2017

Language:

english

File:

PDF, 645 KB

english, 2017

2

Self-amplifying RNA vaccines for infectious diseases

Bloom, Kristie, van den Berg, Fiona, Arbuthnot, Patrick

Journal:

Year:

2020

File:

PDF, 964 KB

2020

3

Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives

Rafique Ul Islam, Justin Hean, Willem A.L. van Otterlo, Charles B. de Koning, Patrick Arbuthnot

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 294 KB

english, 2009

4

Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases

Bloom, Kristie, Ely, Abdullah, Mussolino, Claudio, Cathomen, Toni, Arbuthnot, Patrick

Journal:

Molecular Therapy

Year:

2013

Language:

english

File:

PDF, 2.69 MB

english, 2013

5

Rapid purification of recombinant Taq DNA polymerase by freezing and high temperature thawing of bacterial expression cultures

Grimm, Edith, Arbuthnot, Patrick

Journal:

Nucleic Acids Research

Year:

1995

Language:

english

File:

PDF, 788 KB

english, 1995

6

Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection

Marc S Weinberg,Patrick Arbuthnot

Journal:

Genome Medicine

Year:

2010

Language:

english

File:

PDF, 382 KB

english, 2010

7

Progress with Developing Use of Gene Editing to Cure Chronic Infection with Hepatitis B Virus

Ely, Abdullah, Moyo, Buhle, Arbuthnot, Patrick

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

8

Efficient Silencing of Hepatitis B Virus by Helper-dependent Adenovirus Vector-mediated Delivery of Artificial Antiviral Primary Micro RNAs

Betty Mowa, Mohube, Crowther, Carol, Ely, Abdullah, Arbuthnot, Patrick

Journal:

Year:

2012

Language:

english

File:

PDF, 1.77 MB

english, 2012

9

Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by α-fetoprotein but not insulinlike growth factor II regulatory sequences

Dr. Patrick Arbuthnot, Marie-Pierre Bralet, Helene Thomassin, Jean-Louis Danan, Christian Bréchot, Dr Nicolas Ferry

Journal:

Year:

1995

Language:

english

File:

PDF, 1.19 MB

english, 1995

10

Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of β-catenin

Zhaorui Lian, Jie Liu, Li Li, Xianxing Li, Marcy Clayton, Meng-Chao Wu, Hong-Yang Wang, Patrick Arbuthnot, Michael Kew, Daiming Fan, Mark A. Feitelson

Journal:

Year:

2006

Language:

english

File:

PDF, 2.79 MB

english, 2006

11

Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis

Zhaorui Lian, Jie Liu, Mengchao Wu, Hong-Yang Wang, Patrick Arbuthnot, Michael Kew, Mark A. Feitelson

Journal:

Year:

2007

Language:

english

File:

PDF, 877 KB

english, 2007

12

Increased expression of ErbB-2 in liver is associated with hepatitis B × antigen and shorter survival in patients with liver cancer

Jie Liu, Angela Ahiekpor, Li Li, Xianxing Li, Patrick Arbuthnot, Michael Kew, Mark A. Feitelson

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 562 KB

english, 2009

13

Human S15a expression is upregulated by hepatitis B virus X protein

Zhaorui Lian, Jie Liu, Li Li, Xianxing Li, N. Lale Satiroglu Tufan, Meng-Chao Wu, Hong-Yang Wang, Patrick Arbuthnot, Michael Kew, Mark A. Feitelson

Journal:

Molecular Carcinogenesis

Year:

2004

Language:

english

File:

PDF, 682 KB

english, 2004

14

Regulatory elements of hepatitis B virus transcription

Naazneen Moolla, Michael Kew, Patrick Arbuthnot

Journal:

Journal of Viral Hepatitis

Year:

2002

Language:

english

File:

PDF, 91 KB

english, 2002

15

Putative role of hepatitis B virus X protein in hepatocarcinogenesis: Effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways

Patrick Arbuthnot, Alexio Capovilla, Michael Kew

Journal:

Journal of Gastroenterology and Hepatology

Year:

2000

Language:

english

File:

PDF, 288 KB

english, 2000

16

Countering hepatitis B virus infection using RNAi: how far are we from the clinic?

Dejana Ivacik, Abdullah Ely, Patrick Arbuthnot

Journal:

Reviews in Medical Virology

Year:

2011

Language:

english

File:

PDF, 1.50 MB

english, 2011

17

Hepatitis B virus and hepatocellular carcinoma

Patrick Arbuthnot, Michael Kew

Journal:

International Journal of Experimental Pathology

Year:

2001

Language:

english

File:

PDF, 341 KB

english, 2001

18

Exploiting the RNA interference pathway to counter hepatitis B virus replication

Patrick Arbuthnot, Sergio Carmona, Abdullah Ely

Journal:

Liver International

Year:

2005

Language:

english

File:

PDF, 158 KB

english, 2005

19

The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis

Liu, Jie, Zhang, ShuMin, Zhu, Minghua, Arbuthnot, Patrick, Kew, Michael, Feitelson, Mark A, Pan, Jingbo, Lian, Zhaorui

Journal:

Year:

1999

Language:

english

File:

PDF, 461 KB

english, 1999

20

A cellular gene up-regulated by hepatitis B virus–encoded X antigen promotes hepatocellular growth and survival

Zhaorui Lian, Jie Liu, Jingbo Pan, N.Lale Satiroglu Tufan, Minghua Zhu, Patrick Arbuthnot, Michael Kew, Marcy M. Clayton, Mark A. Feitelson

Journal:

Year:

2001

Language:

english

File:

PDF, 2.80 MB

english, 2001

21

Synthesis of 2′-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus

Jolanta Brzezinska, Jennifer D’Onofrio, Maximilian C.R. Buff, Justin Hean, Abdullah Ely, Musa Marimani, Patrick Arbuthnot, Joachim W. Engels

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 635 KB

english, 2012

22

Hepatitis B Virus X-Protein Binds Damaged DNA and Sensitizes Liver Cells to Ultraviolet Irradiation

Alexio Capovilla, Sergio Carmona, Patrick Arbuthnot

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 408 KB

english, 1997

23

In Situ Demonstration of Inhibitory Effects of Hammerhead Ribozymes That Are Targeted to the Hepatitis Bx Sequence in Cultured Cells

Marc Passman, Marc Weinberg, Michael Kew, Patrick Arbuthnot

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 220 KB

english, 2000

24

MicroRNA-like antivirals

Patrick Arbuthnot

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Year:

2011

Language:

english

File:

PDF, 363 KB

english, 2011

25

Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts

Alexio Capovilla, Patrick Arbuthnot

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003

26

Inhibition of hepatitis B virus replication with linear DNA sequences expressing antiviral micro-RNA shuttles

Saket Chattopadhyay, Abdullah Ely, Kristie Bloom, Marc S. Weinberg, Patrick Arbuthnot

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 436 KB

english, 2009

27

tRNALys3 promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs

Victoria Dyer, Abdullah Ely, Kristie Bloom, Marc Weinberg, Patrick Arbuthnot

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 761 KB

english, 2010

28

Nucleotide excision repair by extracts of human fetal hepatocytes

Alexio Capovilla, Patrick Arbuthnot

Journal:

Year:

2002

Language:

english

File:

PDF, 144 KB

english, 2002

29

Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells

Marc Weinberg, Marc Passman, Michael Kew, Patrick Arbuthnot

Journal:

Journal of Hepatology

Year:

2000

Language:

english

File:

PDF, 1.32 MB

english, 2000

30

Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells

Victoria A Green, Patrick Arbuthnot, Marc S Weinberg

Journal:

Virology Journal

Year:

2012

Language:

english

File:

PDF, 377 KB

english, 2012

31

Hepatitis Bx Antigen Stimulates Expression of a Novel Cellular Gene, URG4, that Promotes Hepatocellular Growth and Survival

Satiroglu Tufan, N. Lale, Lian, Zhaorui, Liu, Jie, Pan, Jingbo, Arbuthnot, Patrick, Kew, Michael, Clayton, Marcy M., Zhu, Minghua, Feitelson, Mark A.

Journal:

Year:

2002

Language:

english

File:

PDF, 664 KB

english, 2002

32

Upregulated Expression of a Unique Gene by Hepatitis B x Antigen Promotes Hepatocellular Growth and Tumorigenesis

Lian, Zhaorui, Liu, Jie, Li, Li, Li, Xianxing, Satiroglu Tutan, N. Lale, Clayton, Marcy, Wu, Meng-Chao, Wang, Hong-Yang, Arbuthnot, Patrick, Kew, Michael, Feitelson, Mark A.

Journal:

Year:

2003

Language:

english

File:

PDF, 4.66 MB

english, 2003

33

Inhibition of hepatitis B virus replication in cultured cells and in vivo using 2′-O-guanidinopropyl modified siRNAs

Marimani, Musa D., Ely, Abdullah, Buff, Maximilian C.R., Bernhardt, Stefan, Engels, Joachim W., Arbuthnot, Patrick

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

34

Controlling HBV Replication in Vivo by Intravenous Administration of Triggered PEGylated siRNA-Nanoparticles

Carmona, Sergio, Jorgensen, Michael R., Kolli, Soumia, Crowther, Carol, Salazar, Felix H., Marion, Patricia L., Fujino, Masato, Natori, Yukikazu, Thanou, Maya, Arbuthnot, Patrick, Miller, Andrew D.

Journal:

Molecular Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 2.59 MB

english, 2009

35

Effective Anti-Hepatitis B Virus Hammerhead Ribozymes Derived from Multimeric Precursors

Weinberg, Marc S., Ely, Abdullah, Passman, Marc, Mufamadi, Steven M., Arbuthnot, Patrick

Journal:

Oligonucleotides

Year:

2007

Language:

english

File:

PDF, 1007 KB

english, 2007

36

Efficient Inhibition of Hepatitis B Virus Replication In Vivo , Using Polyethylene Glycol-Modified Adenovirus Vectors

Crowther, Carol, Ely, Abdullah, Hornby, Judith, Mufamadi, Steven, Salazar, Felix, Marion, Patricia, Arbuthnot, Patrick

Journal:

Human Gene Therapy

Year:

2008

Language:

english

File:

PDF, 271 KB

english, 2008

37

Silencing of HIV-1 Subtype C Primary Isolates by Expressed Small Hairpin RNAs Targeted to gag

Cave, Eleanor, Weinberg, Marc S., Cilliers, Tonie, Carmona, Sergio, Morris, Lynn, Arbuthnot, Patrick

Journal:

AIDS Research and Human Retroviruses

Year:

2006

Language:

english

File:

PDF, 543 KB

english, 2006

38

The Inhibitory Efficacy of RNA POL III-Expressed Long Hairpin RNAs Targeted to Untranslated Regions of the HIV-1 5′ Long Terminal Repeat

Barichievy, Samantha, Saayman, Sheena, von Eije, Karin J., Morris, Kevin V., Arbuthnot, Patrick, Weinberg, Marc S.

Journal:

Oligonucleotides

Year:

2007

Language:

english

File:

PDF, 365 KB

english, 2007

39

In Vitro and In Vivo Hepatoma Cell-Specific Expression of a Gene Transferred with an Adenoviral Vector

Arbuthnot, Patrick B., Bralet, Marie-Pierre, Le Jossic, Catherine, Dedieu, Jean-François, Perricaudet, Michel, Bréchot, Christian, Ferry, Nicolas

Journal:

Human Gene Therapy

Year:

1996

Language:

english

File:

PDF, 14.74 MB

english, 1996

40

Therapeutic potential of adenoviral vectors for delivery of expressed RNAi activators

Mowa, Mohube Betty, Crowther, Carol, Arbuthnot, Patrick

Journal:

Expert Opinion on Drug Delivery

Year:

2010

Language:

english

File:

PDF, 397 KB

english, 2010

41

799. Expressed Long Hairpin RNA Sequences Inhibit HBV Replication In Vivo without Inducing an Interferon Response

Ely, Abdullah, Carmona, Sergio, Crowther, Carol, Mufamadi, Steven, Barichievy, Samantha, Weinberg, Marc, Arbuthnot, Patrick

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

42

Recent advances in developing nucleic acid-based HBV therapy

Marimani, Musa, Hean, Justin, Bloom, Kristie, Ely, Abdullah, Arbuthnot, Patrick

Journal:

Future Microbiology

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

43

Stealth lipoplex decorated with triazole-tethered galactosyl moieties: a strong hepatotropic gene vector

Govender, Dhineshree, Islam, Rafique Ul, De Koning, Charles B., van Otterlo, Willem A. L., Arbuthnot, Patrick, Ariatti, Mario, Singh, Moganavelli

Journal:

Biotechnology Letters

Year:

2015

Language:

english

File:

PDF, 566 KB

english, 2015

44

Transcription Activator-Like Effector (TALE) Nucleases and Repressor TALEs for Antiviral Gene Therapy

Bloom, Kristie, Mussolino, Claudio, Arbuthnot, Patrick

Journal:

Current Stem Cell Reports

Year:

2015

Language:

english

File:

PDF, 600 KB

english, 2015

45

Inhibition of replication of hepatitis B virus in transgenic mice following administration of hepatotropic lipoplexes containing guanidinopropyl-modified siRNAs

Marimani, Musa D., Ely, Abdullah, Buff, Maximilian C.R., Bernhardt, Stefan, Engels, Joachim W., Scherman, Daniel, Escriou, Virginie, Arbuthnot, Patrick

Journal:

Journal of Controlled Release

Year:

2015

Language:

english

File:

PDF, 1.07 MB

english, 2015

46

Hepatitis B virus and hepatocellular carcinoma

Arbuthnot, Patrick, Kew, Michael

Journal:

International Journal of Experimental Pathology

Year:

2001

Language:

english

File:

PDF, 348 KB

english, 2001

47

Gene Therapy for Viral Infections || Essentials of Viruses and their Suitability for Treatment Using Gene Therapy

Arbuthnot, Patrick

Year:

2015

Language:

english

File:

PDF, 1.55 MB

english, 2015

48

Gene Therapy for Viral Infections || Harnessing RNAi to Silence Viral Gene Expression

Arbuthnot, Patrick

Year:

2015

Language:

english

File:

PDF, 1.29 MB

english, 2015

49

Gene Therapy for Viral Infections || Gene Therapy for HIV-1 Infection

Arbuthnot, Patrick

Year:

2015

Language:

english

File:

PDF, 2.31 MB

english, 2015

50

Gene Therapy for Viral Infections || Viral Vectors for Delivery of Antiviral Sequences

Arbuthnot, Patrick

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

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